It is recommend that Kratom not be mixed with stimulant type substances or drugs such as; coffee, amphetamines, yohimbine, and any illegal drugs because of the risk of over-stimulation or increased blood pressure.
It is also recommended that you don’t take Kratom with large amounts of alcohol, benzodiazepines, opiates, or any other type of drug that affects the nervous system. This is because there is a possibility that combining these may cause over-sedation and possibly respiratory distress.
You should also not combine Kratom with any type of MAO inhibitors, because serious and even fatal reactions can occur when mixing these with monoamine drugs, and Kratom contains monoamne alkaloids.
There are some combinations that users have claimed to be both pleasant and safe. You can combine Kratom with regular black tea, and many have mixed it with tea made from red poppy flowers, and tea made from blue lotus. It has also been combined safely with small amounts of alcohol; however Kratom and large amount of alcohol should be avoided.
Many people enjoy smoking tobacco, or herbal smoke while under the influence of kratom, but when doing this you should make sure that you don’t fall asleep and drop lit materials.